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This peptide sequence is found in proteins of the extracellular matrix such as the chain of collagen, and it is believed to be released during wounding and inflammation

The mutations of these genes in Drosophila impaired reversal learning by affecting Rac1-mediated forgetting, and this impairment was rescued by overexpressing constitutively active Rac1 (Dong et al., 2016)

Researchers estimate the difference equated to about four months less biological aging over two years

Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus

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