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The recent demonstration of elevated superoxide dismutase, GSH peroxidase, and total antioxidant capacity in COVID-19 outpatients compared to controls could be interpreted as a response to excessive COVID-19-related oxidative stress (Golabi et al., 2022)

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The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals

While lipid export initially increases, it plateaus and may even decrease with disease progression, sustaining the accumulation of lipids

20 These findings suggest that autophagy and UPS can engage in intertwined pathways to favor ferroptosis