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The problem with natural amylin is that it aggregates rapidly and has a very short half-life, making it impractical for therapeutic use

The proportions of M1M6 and [ 3 H]BPC157 in plasma radioactive components at different sampling times demonstrated that [ 3 H]BPC157 was the main plasma component at 0.05 h (3 min) after administration and was subsequently degraded into small molecular peptide fragments in the following 0.167 h (10 min) (Figure 5A)

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