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Ian Dawes (2021, personal communication) postulated that while the behaviour of the glutathione system is an important part of redox responses in cells, regulatory systems may play a vital role in antioxidant capacity of living organisms

and Type V, although less common, is characterized by fat distribution predominantly in the calves Notably, some literature also describes involvement of the lower abdomen, especially in Types I and II, although this is not consistently reflected across all classification systems.8,15,21,22 Regarding morphological appearance, lipedema progresses through four clinical stages (Table 2): Stage I is characterized by smooth skin with thickened but soft subcutaneous tissue containing small nodules

Some individuals may experience mild discomfort, swelling or redness at the injection site

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doi: 10.1016/s0196-0644(98)70229-x