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Rising liver enzymes warrant further investigation

The conditions most commonly associated with unexplained hypercobalaminemia include: Liver disease

However, these findings have not been observed in human studies, and the clinical relevance remains uncertain

Under these same conditions, no alteration in density or turnover of excitatory connections is observed in the same cells (Hofer et al., 2009), suggesting that structural plasticity of GABA synapses and subsequent rewiring of inhibitory microcircuits is a fundamental mechanism for brain adaptation to sensory experience in layer 2/3 pyramidal cells