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GSH and neurodegeneration The brain is particularly vulnerable to oxidative stress due to relatively lower antioxidant enzyme activities (SOD, GPx, GR and catalase) compared to other tissues

Pediatr Res 93(7):18191827 Hassell KJ, Ezzati M, Alonso-Alconada D, Hausenloy DJ, Robertson NJ (2015) New horizons for newborn brain protection: enhancing endogenous neuroprotection

Recently, our group found that substitution of Ser for Cys would not cause dramatic loss of GPx activity compared to changing those Cys to Sec 15,16

doi: 10.1111/j.1365-2125.2010.03743.x

The use of the nomogram should be avoided until 4 h or more after ingestion as the levels may be misleading during this timeframe from the point of acute ingestion and not be an accurate predictor of toxicity[64,65]