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Despite promising results from preclinical studies, translation of antioxidant or antiinflammatory therapies into clinical success has been hindered by ambiguous molecular mechanisms and inconsistent safety profiles 36,37

If concomitant use of VYVANSE with other serotonergic drugs or CYP2D6 inhibitors is clinically warranted, initiate VYVANSE with lower doses, monitor patients for the emergence of serotonin syndrome during drug initiation or titration, and inform patients of the increased risk for serotonin syndrome

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