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As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide works by enhancing insulin secretion in response to meals, suppressing glucagon release, slowing gastric emptying, and reducing appetite

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MDH2 gene expression was shown to increase with aging in one GABAergic neuron cluster in the hypothalamus (Yang et al., 2008)

Therefore, it is important to highlight how these models have proven to be invaluable in our quest to understanding mitochondrial disorders such as LS