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Author contributions BR: Writing review and editing, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Furthermore, G4C2 repeat RNA and its translation product, dipeptide repeat protein, have been reported to cause neurodegeneration by increasing DNA double-strand breaks, leading to a deficiency of ataxia telangiectasia mutated (ATM), which repairs DNA damage [67]

Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38(+) macrophages and NAD(+) decline