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This inhibition of -KG-dependent enzymes by glutamate is consistent with its role in the epigenetic regulation of CD8 + T cells, such as histone methylation and DNA demethylation [247]

doi: 10.1093/bja/aet173 39 Crumeyrolle-AriasM.JaglinM.BruneauA.VancasselS.CardonaA.DaugV.et al

Our genetic epidemiological findings suggest that in the historically artisanal and smallscale gold mining study population, the genetic variants analyzed in the glutathione-related genes could modulate the pathogenesis of Hg nephrotoxicity by controlling the glutathione concentrations