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First, the IL-6 level, a blood inflammation marker, showed a peak immediately after surgery and decreased thereafter, but it decreased more rapidly in the CT group and became significantly lower compared with the P group on Day 4 after surgery

Conversely, excessive ROS oxidize and damage cellular components, leading to cellular death (Luo et al., 2020

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Given that core metabolic processes, including nucleotide synthesis, glycolysis, and redox defense, are fundamentally shared with normal proliferative tissues, broad-spectrum metabolic inhibition often lacks true selectivity and precipitates dose-limiting systemic toxicities [43]

Additionally, tumor metastasis relies on the development of new blood vessels, a process known as angiogenesis, which selenium has been shown to suppress by modulating the expression of vascular endothelial growth factor (VEGF)