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We attempted next to uncover possible changes in mitochondrial respiration after stimulus with sUA in the presence of LPS by measuring oxygen consumption rates (OCR) of WT, Myd88 / , and Nlrp3 / macrophages

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However, the peptide binds to extracellular matrix proteins in connective tissue and wound healing effects persist 714 days after a single dose, indicating tissue depot retention beyond systemic clearance