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61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent

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CHRM1 knockout mice exhibited accelerated remyelination and reduced axonal loss after EAE induction (Mei et al., 2016)

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