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General Principles of Pharmacology: Drug Metabolism Phase II Detoxification: The Six Conjugation Pathways That Make Toxins Water Soluble MyBioHack Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation Definition, Examples & FAQs JoVE Core Metabolism of acetaminophen in humans. The three pathways, (a) Download Scientific Diagram
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