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Harmaline, a -carboline alkaloid that is found in the plant Peganum harmala , can inhibit the transcription factor Twist1 and restore FAO by upregulating the expression of PGC-1, PPAR and their downstream metabolic enzyme CPT1A, thereby alleviating RF [53]

In the context of IFN- deficiency, IL-4 exerts a suppressive effect on ABC differentiation, and targeted inhibition of IFN- or IL-21 represents a potential therapeutic avenue