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Unresolved issues were as follows: 1) crosstalk between ferroptosis and other cell death pathways (e.g., pyroptosis) in LN, 2) interplay of iron metabolism with epigenetic regulation in ferroptosis-driven autoimmunity, and 3) development of LN-specific ferroptosis inhibitors and sensitive renal biomarkers for clinical translation (225)

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Some absorption of selenium and VE may have occurred by the time of sampling