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Statements Author contributions WJ: Writing original draft

doi: 10.1038/nrn3156 114 OliveiraGDiogoLGrazinaMGarciaPAtaideAMarquesCet al

In the normal state when gluatione stores are adequate gluathione exerts a negative feedback inhibition on the enzyme -glutamyl cysteine synthase which regulates the cycle

Not enough B12 can cause anemia

The first group comprises glutathione disulfide substrates (GSSR) that are reduced by one molecule of GSH, yielding a thiol (RSH) and glutathione disulfide (GSSG) as products (Fig