Disclosures: Robin Kate Kelley: Astra Zeneca: Grant/Research Support, Bayer: Grant/Research Support, Eli Lilly: Grant/Research Support, Exelixis: Grant/Research Support, Genentech/Roche: Grant/Research Support, Kinnate: Consultant, Merck: Grant/Research Support, Partner Therapeutics: Grant/Research Support, Regeneron: Consultant, Agios: Grant/Research Support, BMS: Grant/Research Support, QED: Grant/Research Support, Tyra: Grant/Research Support, Taiho: Grant/Research Support, Surface: Grant/Research Support, Servier: Grant/Research Support, GSK: Consultant, moderna: Consultant, J Pharma Inc.: Consultant, Relay Therapeutics: Grant/Research Support, Young Lee: AstraZeneca PLC: Employee, AstraZeneca PLC: Stock - publicly traded company, James Conway: Nothing to Disclose, John Kurland: Nothing to Disclose, Alejandra Negro: Nothing to Disclose, Patricia McCoon: AstraZeneca: Employee 1832 EMERALD-Y90: A PHASE 2 STUDY TO EVALUATE TRANSARTERIAL RADIOEMBOLIZATION (TARE) FOLLOWED BY DURVALUMAB (D) AND BEVACIZUMAB (B) FOR THE TREATMENT OF PARTICIPANTS (PTS) WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA (UHCC) ELIGIBLE FOR EMBOLIZATION Riad Salem 1 Anne Noonan 2 Ben Spieler 3 Sarah White 4 Laura Kulik 5 Dex Underwood 6 Eric Heilbron 6 Binh Nguyen 6 Graham Wetherill 7 Renuka Iyer 8 , 1 Northwestern University, Chicago, IL, USA, 2 The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA, 3 University of Miami, Miami, FL, USA, 4 Medical College of Wisconsin, Milwaukee, WI, USA, 5 Northwestern Memorial Hospital, Chicago, IL, USA, 6 AstraZeneca, Gaithersburg, MD, USA, 7 AstraZeneca, Cambridge, UK, 8 Roswell Park Cancer Institute, Buffalo, NY, USA Background: Intermediate HCC is often treated with locoregional therapy (LRT), such as transarterial chemoembolization (TACE) or TARE
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Nevertheless, the inability of these approaches to modify the disease process or restore the normal structure, composition, and biomechanical function of the degenerated discs underscores the requirement for developing biological therapies that facilitate disc regeneration
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