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At lower concentrations, GSDMD-NT forms non-lytic pores, which are more conducive to the release of pro-inflammatory cytokines rather than to cell death, compared to higher concentrations [183]

Authors showed that elevated temperature (39-40C) restricts SARS-CoV-2 infection and replication independently of interferon-mediated antiviral defenses

Chen and Gallie 2008)

52 NoelG.DoucetM.NataroJ

Chronic cortisol elevation induces watersodium retention, hypertension, and dyslipidemia, straining cardiac workload and contributing to mood disorders such as depression and anxietyconditions that are often comorbid with HF