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In very rare cases, some individuals notice that their breath or sweat gives off a fishy smell which is a result of the metabolic waste from L-Carnitine

With usual neuroprotective measures, the patient improved after 4 days and finally recovered without sequelae

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13 C NMR (101 MHz, DMSO) 168.56, 143.59, 135.29, 134.10, 133.43, 131.84, 131.08, 130.85, 129.67, 128.44, 123.61, 123.03, 121.76, 120.99, 110.76

Further studies using co-culture, 3D culture, or xenotransplantation of human iPSC-derived neurons and glia generated from patients with or without GRN mutations and/or with the TMEM106B risk or protective haplotype may achieve the goal