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Additionally, FDA/EMA guidelines often demand large-animal safety statistics (e.g., organ toxicity, immunogenicity) before initiating clinical trials, since rodents cannot predict human side effects accurately [185]

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10.1002/1873-3468.13101 29 Oseguera-LpezI.Ruiz-DazS.Ramos-IbeasP.Prez-CerezalesS

FIGURE 3 Furthermore, depletion of NAD+/NADH has been shown to leads to membrane depolarization, mitophagy and cell death via apoptosis or ferroptosis (Figure 3C clearly shows that ER induced significant polarization of both cells within 4 h of treatment