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Although protective drugs have also been discovered, the studies had limitations, including their small sample sizes and failure to explore the mechanisms in-depth, and the clinical relevance of the findings has yet to be verified

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This can be achieved by changing a few parameters, like medium composition and providing better aeration by vigorous shaking (McDaniel and Bailey, 1969

thaliana expressing the rat neuronal nitric oxide synthase (NOS) behind a 35S promoter accumulated high levels of NO concomitant with developmental defects and altered stress resistance (Chun et al., 2012)

In the setting of hyperlipidemia, the pathological effect of transsulfuration pathway on redox status is not that simple, because in normal physiological settings, the flux of homocysteine to GSH through the transsulfuration pathway can be compensatively enhanced in response to the oxidative stress in order to maintain the oxidant/antioxidant balance whereas antioxidant treatment elicit the opposite effect on transsulfuration pathway [8]