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Managing Discontinuation Effects and Safer Alternatives Rather than stopping abruptly, many physicians recommend a gradual dose reduction over 48 weeks

Gao XF, Wang W, Yu Q, Burnstock G, Xiang ZH

This is followed by multiple immune abnormalities: marked impairment of the immunosuppressive function of myeloid-derived suppressor cells (MDSCs), pro-inflammatory polarization of Kupffer cells, T-cell differentiation imbalance, and B-cell hyperactivation that induces antimitochondrial antibody (AMA)-mediated cytotoxicity

The choice of procedure depends on the condition, like stomach cancer, severe ulcers, or obesity

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