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Modification of oxidative stress by pioglitazone in the heart of alloxan-induced diabetic rabbits

McKinnon MC, Cusi AM, MacQueen GM

Since gain-of-function mutations in NLRP3 were demonstrated to cause a rare autoinflammatory disease termed cryopyrin-associated periodic syndrome, NLRP3 has emerged as key mediator of inflammation in mouse models for many common diseases, including atherosclerosis, Alzheimers disease and gout

While some polyphenol-rich extracts, such as grape seed extract, have shown high tolerability in animal and short-term human studies, the safety of long-term, high-dose intake across a broad population spectrum remains to be confirmed (122, 123)

Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)