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Meta-regression showed that mean age had no significant influence (coefficient = 0.3, p = 0.191), while mechanical ventilation duration strongly predicted mortality (coefficient = 0.527, p 25 (1.36, 1.11-1.66)

Repeated dosing studies in rats, dogs, and mice for up to 6 weeks across doses from 0.006 mg/kg to 20 mg/kg via multiple routes showed excellent tolerance

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Each animal was measured three times, and the average results were then statistically examined