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In the dataset from Govaere et al., more than 200 individual liver biopsies from patients were histologically scored to determine MASLD/MASH stage, followed by RNA-seq for transcriptomic profiling (46) (Figure 6C)

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Seven of the nine pathways were involved in amino acid metabolism, and another was peroxisome proliferator-activated receptor (PPAR) signaling, which is a potent regulator of cellular metabolism

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