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PMC 528928

Table 1 summarizes the effects of the main flavonoids explored in this section, highlighting the main dietary sources, mechanisms of action described in preclinical studies and clinical trials/studies in humans with doses used, if pertinent

The invariant cis -Pro residue is located in the loop region before 3 and is thought to be implicated in the maintenance of the enzyme fold rather than playing a role in the enzymatic reaction (Figure 3A) (Allocati et al., cis -proline is hydrogen-bonded to the backbone of CysGS (cysteine residue of glutathione) (Figure 3A)