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361 Pharmacological side effects of COX-2 are related to the inhibition of prostacycline, which protects vascular endothelial cells, dilates blood vessels, and inhibits platelet aggregation and thrombosis

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Their complementary mechanisms one acting primarily through growth factor upregulation and GI-cytoprotection, the other through actin polymerization and systemic cell migration make them uniquely interesting both individually and as a combined research subject

In contrast, a simple fracture line in the endplate that is closed maybe less problematic and no or only minor loss of NP material is expected