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Description

Smad7 is a key endogenous inhibitor of the TGF-/Smad signaling pathway (Liu Z

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The enzyme uses either iron or manganese as a cofactor and catalyzes the degradation or reduction of hydrogen peroxide (H2O2) to water and molecular oxygen, consequently completing the detoxification process imitated by SOD.35, 36 It is abundant in cells, where it continuously scouts for hydrogen peroxide molecules