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Reported Mild Effects: Temporary injection site redness Slight drowsiness (when dosed in evening) Vivid dreams or altered sleep patterns Mild headaches during initial days Management Strategies: Rotate injection sites regularly Reduce dosage if effects seem excessive Maintain hydration throughout protocol Consider timing adjustments for sleep-related effects When to Modify or Discontinue Certain situations warrant protocol modifications or discontinuation

To elucidate the therapeutic potential of targeting VEGF signaling in EAE, mice were treated with the selective VEGF receptor inhibitor semaxinib (Roscoe and Welsh 2009)

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