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For MSI and LCMS analysis of individual organs, the samples were collected as follows: After the infusion, blood was collected from the orbital sinus, and the mouse was euthanized

Glutathione is the major detoxification molecule found in every cell of the body

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Treg ferroptosis Tregs, a subset of CD4 + T cells [105], can induce dysfunction in CD8 + T cells and facilitate immune evasion by tumor cells through IL-2 (enhance the proliferation and cytotoxic activity of CD8 + T cells) deprivation, upregulation of PD-1 and CTLA-4 expression as well as IL-10 and TGF- secretion, among other mechanisms [106]

The levels of SIRT6 were found to be elevated in the synovial tissue of smokers with RA and in the joints of mice exposed to cigarette smoke