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Since tirzepatide may slow gastric emptying as part of its mechanism of action, patients with pre-existing severe gastroparesis could experience worsening of symptoms, including nausea, vomiting, and potential complications related to delayed gastric emptying

In relation to AT remodelling, it was shown that p53 signalling is induced in adipocytes upon obesity development in mice, causing adipocyte senescence, AT inflammation, and systemic insulin resistance 24,70

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NAPQI is also an inhibitor of enzymes in the vitamin K cycle

This polymorphism is found in the heme biosynthesis pathway where it has been associated with altered toxicokinetics of lead levels and elevated blood levels of lead [100102]