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In addition, a delayed sustained inflammatory response has been observed days after implementation of VA-ECMO, of which the underlying mechanism may be the presence of low circulating endotoxin concentrations that sustain complement activation and cytokine release (122, 123)

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However, GI AE are usually mild-to-moderate, transient, partially preventable, and rarely lead to treatment discontinuation 107

Coeliac disease sprue primarily affects the small intestine, damaging the villi responsible for nutrient absorption