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References de Moffarts, B., et al

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however, it is highly recommended to conduct a patch test prior to regular application of skincare products.[4] Users should discontinue use if they experience any signs of allergic reactions, such as redness, hives, or itchiness.[5] While copper can potentially cause skin irritation or toxicity, in vitro studies suggest that GHK-Cu complexes may have a lower likelihood of inducing these effects.[6] However, it is always recommended to consult a healthcare professional before using any new skincare product

Although most families of CA require Zn, some diatoms express a Cd-utilizing carbonic anhydrase (CDCA) that can function with either Zn or Cd