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Carlile GW, Smith DH, Wiedmann M

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This means a vial reconstituted for the 2mg phase (which provides 5 weekly doses from a 10mg vial) should be used within about 5 weeks, which aligns perfectly with the 4-week dose escalation schedule plus a small buffer

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Common reasons for deprescribing include No active indication (e.g., health condition resolved) New or worsening condition Potential risks outweigh anticipated benefits Preventive indication with life-limiting conditions Lack of benefit or ineffectiveness Result of a prescribing cascade Nonadherence Interactions or ADEs Prescribers and pharmacists can use the available prescribing and deprescribing clinical tools, but they must also review all medications and assess the benefit versus risk for individualized patients