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6.2 Hypoxia In the normal adult intervertebral disc (IVD), oxygen partial pressure gradually decreases from about 10% in the outer annulus fibrosus to less than 1% in the central region, placing the entire disc in a state of continuous hypoxia, which may further decrease during degeneration (Urban, 2002)

Under-methylation Under-methylation occurs when the synthesis of SAM in the methionine cycle is disturbed

While systemic dihexa half life remains one to two hours, CNS concentrations may persist for four to six hours because the peptide is delivered to the target site without requiring blood-brain barrier penetration

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doi: 10.1038/s41588-018-0248-z [DOI] [PMC free article] [PubMed] [Google Scholar] 73