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Primary GBM is associated with mutations of genes, which regulate RB/E2F pathway

Similar to previous studies in salivary glands (Avila et al , 2009), we found a 10 Gy dose induces DNA damage and cell cycle arrest, as well as reduces cell proliferation in the SLG in the first day following IR, as shown by a substantial increase in the proapoptotic gene Bax and the cell cycle inhibitor Cdkn1a (p21) (Fig EV4A) and a reduction in transcript levels of the cell proliferation marker Mki67 (Fig EV4A)

They are capable of sensing a variety of pathogens, cellular damage signals, or metabolic abnormalities, which trigger the activation of downstream caspase-1

They also have lower glutathione levels

Song A., Zhu X., Chen F., Gao H., Jiang J., Chen S