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CBS (homocysteinemia/cystathionine beta-synthase deficiency)

More subtype-specific preclinical trials are expected to further explore the drug advantages

The magnetic field-responsive nanomaterial Ferumoxytol has been approved by the FDA for the treatment of anemia and shows promising potential in tumor diagnosis and targeted therapy (Long et al., 2024b)

Enhanced permeation and retention (EPR) effect The phenomenon of elevated retention of nanomaterials in certain diseased tissues (for example, tumours and sites of inflammation) owing to leaky vessels and poor lymphatic drainage

For instance, reversed were increased number of inflammatory cells (38, 44-46) and the rise of leukotriene B4 (LTB4), thromboxane B2 (TXB2), and myeloperoxidase (MPO) in the serum and inflamed tissues (47-49)