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Above roughly 50-60 mcg/day, side-effect frequency rises faster than the perceived signaling benefit

Unlike trigeminal neuralgia, which involves short (seconds to minutes) episodic, sharp, electric-like pain affecting one or more branches of the trigeminal nerve, CTN often manifests as continuous pain or sensory disturbances [1]

Liao D, Tan H, Hui R, Li Z, Jiang X, Gaubatz J, Yang F, Durante W, Chan L, Schafer AI, Pownall HJ, Yang X, Wang H (2006) Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance

In some cases, a procedure called patellar tendon release may be necessary