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Tosic M, Ott J, Barral S, Bovet P, Deppen P, Gheorghita F, et al

found that in aortic valve stenosis, exogenous H 2 S activates the NRF2SQOR pathway, upregulating SQOR and NRF2 and inducing autophagy as well as antioxidant genes (e.g., NQO1 , CSE )

Oxidative stress primarily refers to the process of oxidative damage resulting from an imbalance between oxidative and antioxidant systems in cells and tissues, leading to the accumulation of free radicals and ROS (41)