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Not only did patients lose weight as expected -- an average of 4.4 kg from baseline -- but triglyceride and low-density lipoprotein (LDL) cholesterol levels also declined significantly

Representative study selection From the extensive pool of studies, those that provided clear, reproducible, and significant outcomes were selected as representative examples

Alternatively, the suppression of the lipid flippase solute carrier family 47 member 1 (SLC47A1) enhances ferroptosis by favoring the ACSL4sterol O-acyltransferase 1 (SOAT1) pathway over the ACSL4LPCAT3 pathway, leading to the production of PUFA cholesterol esters in pancreatic cancer cells [102]

The maximal L-lactate in pyruvate dehydrogenase deficiency is nearly identical to the maximal D-lactate in LDHD deficiency, and including the pyruvate to represent the totality of what is blocked by the mutation in the enzyme does not meaningfully change the comparison

1c and Supplementary Table 2)