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Key characteristics of SOD2 include: Contains manganese as a cofactor Forms a homotetramer (four identical subunits) Encoded by nuclear DNA but transported to mitochondria Expression levels can be induced by oxidative stress and inflammatory cytokines Essential for life, as SOD2 knockout mice die soon after birth SOD2's role in protecting mitochondria from oxidative damage is particularly important for tissues with high energy demands, such as heart, brain, and muscle

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Collectively, these findings indicate that HMLRPP NPs effectively modulate ferroptosis and represent a potential AS treatment strategy with high bioavailability and low side effects