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We also noted downregulation of the DE patterning gene Orthodenticle Homeobox 2 ( OTX2 ) and increased expression of Transcription Factor AP-2 Gamma ( TFAP2C ), which is upregulated in OTX2 -deficient human DE 32

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In comparison, oral supplements lose a portion of their effectiveness as they pass through the digestive system, and they can take longer to show results