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some microbially modified bile acids (like iso-deoxycholic acid) can cross into the brain and have been shown to modulate microglial activity and cholesterol metabolism in neurons [80]

doi: 10.1152/ajpcell.00356.2006 7 AllamanI.BlangerM.MagistrettiP

Addition of NAC to GSTP-silenced cells on Day 2 of the siRNA transfection showed very little restoration of the proportion of polarized mitochondria two days later, although a significant recovery was displayed compared to GSTP-silenced cells (Fig

A deeper understanding of these interconnected metabolic networks clarifies the critical role of ferroptosis in OA progression and lays a robust foundation for integrated therapeutic strategies targeting both metabolic reprogramming and ferroptosis