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Miscellaneous agents comprise alpha-1 blockers (prazosin, terazosin, and doxazosin) that block 1 -adrenergic receptors, thereby inhibiting vasoconstriction induced by catecholamines

Berberine should be avoided by those who are pregnant or breastfeeding, as it may worsen jaundice in infants or result in kernicterus, a condition in which prolonged high bilirubin levels can cause irreversible effects (28)

PLB has been shown to exert its anti-inflammatory and antioxidant effects by inhibiting signaling pathways such as PI3K/Akt/mTOR and nuclear factor-kappaB [34, 35]

The active site of GPX4, selenocysteine, alternates between reduced and oxidized states to sustain its catalytic activity