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Complex systems are now recognized as demonstrating emergent behavior, with functions arising from the totality of system interactions, which are often nonlinear and stochastic

Nevertheless, if we compare the internal states corresponding to Nrf2Keap1 complexes (Fig 3D), the dissociation model predicts an immediate decrease in the complex upon exposure to DEM followed by a sharp increase in complex formation, while the hinge-latch model predicts a prolonged increase in the complex that starts immediately upon oxidative stress

Frontiers in Plant Science , Volume 11 - 2020

Despite these advances, the exact antiviral mechanisms of many ferroptosis regulators remain inadequately understood and require further study

This will ultimately provide a rational basis for clinical practice