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In the UK, healthcare professionals are advised to check and monitor serum vitamin B12 levels in patients treated with metformin and who have symptoms suggestive of vitamin B12 deficiency ( levels-new-advice-for-monitoring-patients-at-risk)

In fact, the liver stores so much B12 that it can take years for a deficiency to develop (EFSA, 2015

1 2 Proceedings of the National Academy of Sciences of the United States of America