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Among the most prominently affected pathways were pyrimidine metabolism, purine metabolism, and alanine, aspartate, and glutamate metabolism, highlighting widespread perturbation of nucleotide biosynthesis and amino acidlinked metabolic flux following DHODH inhibition

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Table 1 Leipzig scoring system for the diagnosis of Wilson disease a

Common side effects reported include transient hypotension, nausea, abdominal pain, diarrhea, itching, irritation at the injection site, erythema, and alterations in serum protein levels

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