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The AMPK pathway becomes active in response to insufficient cellular ATP levels which then leads to mTORC1 inhibition and diminished glutamine transporter expression

Given its participation in the initiation and development of HCC, Hh targeted therapies could be a hopeful strategy to fight against HCC

Under this metabolic stress, SW48 +/G12D and SW48 +/G12V cells notably exhibited increased resilience and enhanced viability in low glucose/high glutamine environments (Fig

This process involves oxidative phosphorylation, which utilizes oxygen to release the energy contained in the foods we eat

doi: 10.1073/pnas.1813458115 20 WangXSatoRBrownMSHuaXGoldsteinJL