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1015 During skin aging, alterations in the shape of keratinocytes occur, and the epidermal-dermal junction (rete pegs) flattens, while the dermis decreases in thickness and declination of rebound is observed due to the loss of collagen, elastin, and hyaluronic acid

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Toxicokinetic analysis Male and female rats and monkeys were assigned to three treatment groups (n = 6 per group